UroToday4d
Sarcomatoid areas of urothelial carcinoma are enriched for CD163-positive antigen-presenting cells.
Sarcomatoid urothelial carcinoma (SUC) is a rare histologic subtype with poor prognosis. While there is known intra-tumoral heterogeneity between individual SUC tumors, the relationship between ...
UroToday5d
On-treatment PSA kinetics as a potential biomarker: Guiding personalized treatment in metastatic hormone-sensitive prostate cancer.
In this issue of Med, Bian et al. present a post-hoc analysis of the phase 3 CHART trial investigating rezvilutamide in the metastatic hormone-sensitive prostate cancer setting.1 They show that ...
UroToday6d
Active Surveillance Follow-Up for Prostate Cancer: From Guidelines to Real-World Clinical Practice - Beyond the Abstract
Active surveillance (AS) has been a game-changer in managing low-risk prostate cancer (PCa), offering men the chance to avoid overtreatment while keeping a close watch on disease progression. However, ...
UroToday5d
Is There a Minimum Percentage of Sarcomatoid Component Required to Affect Outcomes of Localised Renal Cell Carcinoma? - Beyond the Abstract
Sarcomatoid differentiation is an example of epithelial-mesenchymal transition and is present in 5% of localized and 20% of metastatic RCC. Although the impacts of pathological characteristics and the ...
UroToday4d
Risk of invasive penile cancer after treatment of penile intraepithelial neoplasia.
To examine the risk of progression and time to progression from penile intraepithelial neoplasia (PeIN) to invasive penile cancer in patients treated for PeIN with either surgery, laser ablation or ...
UroToday6d
FDA Authorizes ImmunityBio to Provide Recombinant BCG (rBCG) to Urologists to Address TICE® BCG Shortage
Next-generation recombinant Bacillus Calmette-Guérin (rBCG) has undergone Phase 2 clinical trials in Europe in non-muscle invasive bladder cancer (NMIBC) Supplies of rBCG are now available, with ...
UroToday6d
New Advancements in Prognostic Biomarkers for Upper Tract Urothelial Carcinoma.
As research on upper tract urothelial carcinoma (UTUC) has deepened, the value of biomarkers in the prognostic evaluation of UTUC has been gradually highlighted. As a high-grade epithelial tumor ...
UroToday4d
Comparative analysis of trifecta and pentafecta outcomes in T1a and T1b renal tumors following robotic partial nephrectomy: a retrospective study.
This study aims to conduct a comparative analysis of Trifecta and Pentafecta outcomes between T1a and T1b renal tumors in patients undergoing robotic partial nephrectomy (RAPN). We explore the ...
UroToday5d
Treatment strategies in human papillomavirus-related advanced penile cancer.
Penile cancer is a rare neoplasm with heterogeneous prevalence influenced by risk factors such as smoking, poor hygiene and human papillomavirus (HPV) infection. Southern Africa, South America and ...
UroToday5d
Are Patients with Prostate Imaging Reporting and Data System 5 Lesions Eligible for Active Surveillance? A Multicentric European Study.
Patients with Prostate Imaging Reporting and Data System (PI-RADS) 5 lesions are at a high risk of clinically significant prostate cancer (PCa), extracapsular extension, and biochemical recurrence ...
UroToday5d
Navigating advanced renal cell carcinoma in the era of artificial intelligence.
Research has helped to better understand renal cell carcinoma and enhance management of patients with locally advanced and metastatic disease. More recently, artificial intelligence has emerged as a ...
UroToday5d
CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer.
Amplification of the androgen receptor (AR) locus is the most frequent alteration in metastatic castration-resistant prostate cancer (CRPC). Recently, it was discovered that an enhancer of the AR is ...