A 41-year-old man was evaluated for swelling in the ankles and syncope. CT of the chest showed bilateral mediastinal and ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Two patients with congenital generalized lipodystrophy type 1 due to a variant in AGPAT2 (c.589-2A→G) who had been receiving insulin and metreleptin were switched to tirzepatide and were ...

For decades after the identification of mpox in humans in the Democratic Republic of Congo (DRC) in 1970, the disease was largely confined to the rural areas of Central and West Africa and thus ...

For decades, poor treatment options and low-quality evidence plagued care for patients with rifampin-resistant tuberculosis. The advent of new drugs to treat tuberculosis and enhanced funding now ...

Rifampin-resistant tuberculosis has traditionally been treated with 18-to-24-month regimens, but shorter, all-oral regimens may offer efficacious alternatives. New research findings are summarized ...

This feature about a child unvaccinated against measles, mumps, and rubella offers a case vignette accompanied by two essays, one supporting accepting the child as a patient without mandating the ...

This letter reports an association between acquired osteomalacia and autoantibodies against PHEX (phosphate-regulating endopeptidase X-linked), which may be termed autoimmune osteomalacia.

To the Editor: The results of the SENIOR-RITA (Older Patients with Non–ST-Segment Elevation Myocardial Infarction Randomized Interventional Treatment) trial by Kunadian et al. (Nov. 7 issue) 1 ...

A previously healthy 10-month-old girl presented with an intermittently itchy and swollen skin lesion on the neck. When rubbed, the lesion became edematous with a flare of surrounding erythema.

Mpox has been endemic in remote, rural areas of Africa for decades but has attracted relatively little attention until the global outbreak that began in 2022. In July of that year, I declared a ...