The case description for a Case Records of the Massachusetts General Hospital appears below. A 56-year-old woman experiencing homelessness was evaluated at this hospital because of sore throat and ...

In bronchiectasis, neutrophilic inflammation is associated with an increased risk of exacerbations and disease progression. Brensocatib, an oral, reversible inhibitor of dipeptidyl peptidase 1 ...

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele ...

Baloxavir marboxil (baloxavir) rapidly reduces influenza virus shedding, which suggests that it may reduce transmission. Studies of treatment with neuraminidase inhibitors have not shown ...

Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this ...

Antiviral treatment of influenza is recommended as soon as possible for hospitalized patients and for outpatients who are at increased risk for influenza-related complications. 1,2 The Food and ...

Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production. 1 Clonal ...

Details and references regarding individual diseases are provided in the Supplementary Appendix. CIDP denotes chronic inflammatory demyelinating polyneuropathy, Covid-19 coronavirus disease 2019 ...

To the Editor: Packer et al. (Jan. 30 issue) 1 report the highly anticipated results of the SUMMIT trial, which compared tirzepatide with placebo in patients with heart failure with preserved ...

In this NEJM Outbreaks Update, Editor-in-Chief Eric Rubin and Deputy Editor Lindsey Baden are joined by Indiana Commissioner of Public Health Lindsay Weaver to discuss the current state of avian ...

A 3-year-old boy presented with a 6-week history of ulcerated plaques with rolled borders and satellite papules on his left lower leg. He had recently immigrated from Venezuela after a long ...

A 56-year-old woman experiencing homelessness was evaluated at this hospital because of sore throat and a pruritic rash on her face, chest, abdomen, and legs. A diagnosis was made. This case was ...