Though the wall-to-wall 2025 NCAA Tournament action won't get started until Thursday's first-round schedule, the First Four in Dayton has become a staple in its decade-plus of existence that provides a unique kickoff to March Madness.

Winning March Madness is one of the hardest things to do in sports. After playing a full four-month regular season from November through March, a team must win at least six pressure-packed NCAA Tournament games against some of the best basketball schools in the country.

Every set of betting lines, spreads, totals and more betting odds for the first four and opening round of the 2025 Women's March Madness.