Background Treatment strategies for Crohn’s disease (CD) suppress diverse inflammatory pathways but many patients remain refractory to treatment. Autologous haematopoietic stem cell transplantation ...

Background and aims Quantifying systemic inflammation (SI) in acutely decompensated cirrhosis (ADC) is of major importance because SI is a driver of the most severe forms of ADC, including ...

2 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore Design Experts in microbiome research, microbiology, gastroenterology, internal medicine and biotherapeutics industry ...

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Objective To develop an interpretable artificial intelligence algorithm to rule out normal large bowel endoscopic biopsies, saving pathologist resources and helping with early diagnosis. Design A ...

Over the past two decades a growing body of evidence has demonstrated an important role of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease. On one side, TJ ...

1 Department of Gastroenterology, The General Infirmary at Leeds, Leeds, UK 2 Department of Histopathology, The General Infirmary at Leeds, Leeds, UK 3 Department of Gastroenterology, The General ...

Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany Correspondence to Dr Christoph Becker, 1. Department of Medicine, University of Erlangen-Nuremberg, Hartmannstrasse 14, 91 ...

Background and aims Acute-on-chronic liver failure (ACLF) is characterised by acute decompensation of cirrhosis associated with organ failures. We systematically evaluated the geographical variations ...

2 Department of Primary Care and Public Health Sciences, King's College London, London, UK Methods Material and Methods: This was a single centre, double blind, randomised, placebo controlled trial ...

Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...

Introduction Steroids have been an established treatment in flares of inflammatory bowel disease (IBD) for the past 50 years. Whilst evidence exists to guide the initial dose of these drugs, data ...