Prince Frederik, the son of Europe's Prince Robert of Luxembourg, has died from a rare genetic disease, his family announced.

Prince Frederik of Luxembourg asked his father one final powerful question before dying from a rare POLG Mitochondrial disease aged 22.

The beloved royal died on March 1 from POLG Mitochondrial disease — a rare genetic disorder that affects approximately one in 5,000 people. The genetic disorder affects multiple organ systems and the mitochondria,